Joachim Andersen is also wanted by Arsenal (Getty Images)Praet, a Belgian central midfielder, scored two goals and registered three assists in 37 appearances for Sampdoria this season.AdvertisementAdvertisementThe 25-year-old also went on trial at Arsenal when he was 16 but opted to remain in Belgium and join Anderlecht instead of moving to the Gunners.More: FootballRio Ferdinand urges Ole Gunnar Solskjaer to drop Manchester United starChelsea defender Fikayo Tomori reveals why he made U-turn over transfer deadline day moveMikel Arteta rates Thomas Partey’s chances of making his Arsenal debut vs Man CityAndersen, meanwhile, is one of Serie A’s top central defenders and is viewed by Arsenal as a long-term successor to Laurent Koscielny.Tottenham have also been linked with a move for the Denmark international.More: Arsenal FCArsenal flop Denis Suarez delivers verdict on Thomas Partey and Lucas Torreira movesThomas Partey debut? Ian Wright picks his Arsenal starting XI vs Manchester CityArsene Wenger explains why Mikel Arteta is ‘lucky’ to be managing Arsenal Comment Arsenal submit improved £44m offer to sign Sampdoria duo Dennis Praet and Joachim Andersen Arsenal have launched a new bid for Sampdoria midfielder Dennis Praet (Getty Images)Arsenal have submitted a new €50 million (£44m) bid to sign Sampdoria duo Dennis Praet and Joachim Andersen, according to reports.Earlier this week, reports in Italy claimed that the Gunners had tabled a €42m (£37m) offer for the two players, but the bid was turned down by Sampdoria.According to Sampnews24, who revealed the first details of Lucas Torreira’s move from Sampdoria to Arsenal last year, Arsenal have returned with an improved offer for Praet and Andersen.And the report claims that Sampdoria president Massimo Ferrero is ready to accept Arsenal’s new bid.ADVERTISEMENT Advertisement Advertisement Metro Sport ReporterThursday 6 Jun 2019 6:06 pmShare this article via facebookShare this article via twitterShare this article via messengerShare this with Share this article via emailShare this article via flipboardCopy link4.8kShares
By Ed OsmondLONDON, England (Reuters) – England’s batting frailties were exposed again as they wasted a solid start and laboured to 271 for eight on the first day of the final Ashes Test against Australia at The Oval yesterday.The Australians, who have retained the Ashes, dropped England captain Joe Root three times as he made 57 but the hosts failed to take full advantage and only Jos Buttler’s late unbeaten 64 saved them from complete collapse.“The boys batted really well in the morning and we got ourselves into a fantastic position but could not capitalise,” Buttler said. “Both sides are feeling a long series with a quick turnaround between Tests so that’s why the intensity goes up and down. Australia have a really good bowling attack and asked questions all day. It’s frustrating for us not being able to capitalise on our start.”Medium-pacer Mitchell Marsh took four wickets to boost Australia’s bid to secure a 3-1 series win after their captain Tim Paine won the toss and surprisingly sent England in to bat. Pat Cummins and Josh Hazlewood bowled tidy opening spells but the touring side’s vaunted pace attack lacked the consistent threat which has caused problems for England’s fragile top order throughout the series.Joe Denly, on 14, played a loose stroke at a wide delivery from Cummins and edged to second slip where Steve Smith fumbled the chance before grabbing the ball before it hit the ground.The opening partnership of 27 was the highest of the series but it was another failure for the 33-year-old Denly, who made battling fifties in the last two Tests without staking a claim to a long-term place in the team.CHARMED LIFERoot, badly dropped on 24 by Peter Siddle at fine leg, after playing a casual pull stroke, was also put down by wicketkeeper Paine off Cummins and England reached lunch at 86-1.Root was given another life when Smith spilled a sharp chance in the slips but Rory Burns hit seven fours in another determined knock. The young opening batsman was three runs away from his half-century when he got cramped up by a short ball from Hazlewood and spooned a simple catch to Marsh at mid-wicket.Ben Stokes, loudly cheered to the wicket after his match-winning century in the third Test, cautiously moved to 20 before he was tempted into a wild heave at medium-pacer Marsh and the ball looped off a leading edge to point.Root got to a patient fifty, off 105 balls, and his side moved on to 169-3 at tea, but any hopes England had of a substantial score disappeared in the final session. Root was bowled by a fine Cummins delivery which hit his off stump and Jonny Bairstow was trapped lbw for 22 by a Marsh yorker.Sam Curran hooked Cummins for an audacious six, but two deliveries later the young all-rounder was adjudged lbw, only to be recalled to the crease because Cummins had bowled a no-ball.His reprieve was short-lived, however, as Curran edged Marsh to Smith at second slip for 15 and the same bowler snared Chris Woakes lbw to claim his fourth wicket on his recall to the side.“I was like a kid at Christmas this morning,” Marsh said. “It can be a long tour when you are not playing. I just wanted to try and get an opportunity at some stage and it was nice to produce today. The ball came out reasonably well.” Jofra Archer then nicked Hazlewood to Paine before Buttler briefly lifted the crowd by hitting Hazlewood for two sixes in a row.Buttler pulled Hazlewood over the ropes again to reach his fifty and with Jack Leach providing obdurate support, the ninth-wicket pair shared an unbroken stand of 45 to boost England’s chances of levelling the series.ENGLAND 1st innings R. Burns c Marsh b Hazlewood 47J. Denly c Smith b Cummins 14J. Root (c) b Cummins 57B. Stokes c Lyon b Marsh 20J. Bairstow lbw b Marsh 22J. Buttler not out 64S. Curran c Smith b Marsh 15C. Woakes lbw b Marsh 2J. Archer c Paine b Hazlewood 9M. Leach not out 10Extras: (b-2, lb-7, nb-2) 11Total: (8 wickets, 82 overs) 271Fall of wickets: 1-27, 2-103, 3-130, 4-170, 5-176, 6-199, 7-205, 8-226.Bowling: P. Cummins 22.5-5-73-2, J. Hazlewood 21-7-76-2, P Siddle 17-1-61-0, M. Marsh 16.1-4-35-4, N. Lyon 4-0-12-0, M. Labuschagne 1-0-5-0.
In the final hour of the January window, Stoke announced the capture of highly-rated defensive midfielder Giannelli Imbula from FC Porto for 18.3 million pounds.The French international has signed a five-and-a-half year deal at the Britannia Stadium.That deal bettered the 13.5 million pounds that Everton paid for Senegalese striker Oumar Niasse from Lokomotiv Moscow after Irish international Aiden McGeady had earlier been allowed to leave Goodison Park to join Sheffield Wednesday on-loan for the season.
Reviewed by James Ives, M.Psych. (Editor)Sep 6 2018A National Institutes of Health grant will help LSU Pennington Biomedical Research Center take the next step to better understanding how to prevent the kidney damage and failure caused by type 2 diabetes.Krisztian Stadler, PhD, director of the center’s Oxidative Stress and Disease Laboratory, won the NIH R01 grant valued at $1.75 million over four years.”Kidney disease is a major complication of obesity and type 2 diabetes,” Dr. Stadler said. “Our projects focus on discovering the mechanisms that lead to the death of proximal tubular epithelial cells.”Tubular epithelial cells play a crucial role in kidney function, and the cells require high amounts of a specific type of energy source to work correctly – lipids and fatty acids, Dr. Stadler said. Unfortunately, people with type 2 diabetes have lipid metabolism derailments. Their kidney tubular cells can’t properly burn fat or make enough of the molecule adenosine 5′-triphosphate (ATP) to meet the cells’ energy needs. Without enough ATP, tubular epithelial cells wither and die.Related StoriesAMSBIO offers new, best-in-class CAR-T cell range for research and immunotherapyResearch sheds light on sun-induced DNA damage and repairChronic kidney disease patients are excluded from clinical trials”Our hope is that by understanding these mechanisms, future interventions can be designed not only to treat but to prevent tubular cell injury and kidney failure,” Dr. Stadler said.Diabetes is the leading cause of chronic and end-stage kidney disease, according to a 2016 article published in JAMA. An estimated 26 percent of U.S. adults with diabetes, or roughly 8.2 million people, have some form of kidney disease.Kidney damage begins long before the symptoms manifest. If the damage continues, a person’s kidneys can fail, according to the National Institutes of Health. The treatment for kidney failure is dialysis or a kidney transplant. More than half of diabetics with kidney failure have type 2 diabetes.More than 30 million Americans have diabetes, and 90 percent to 95 percent of them have type 2 diabetes, according to the U.S. Centers for Disease Control and Prevention. An additional 84.1 million Americans have prediabetes, a condition that if left untreated often leads to type 2 diabetes within five years.Although type 2 diabetes most frequently occurs in people over 40, increasing numbers of children, teens and young adults are developing the disease.R01 grants, or Research Project Grants, provide support for health-related research and development. The program, NIH’s original and oldest grant mechanism, is highly competitive. Less than 19 percent of applicants received funding in the 2017 fiscal year, which ended Sept. 30. Source:https://www.lsu.edu/